National Chromatography Inco
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Ultimasyil Diol HPLC Columns (100Å) are designed for normal-phase, reversed-phase, and HILIC (Hydrophilic Interaction Liquid Chromatography) applications. These columns feature a diol (–CH₂–CHOH–CH₂OH) bonded phase on high-purity silica, offering moderate polarity and reduced reactivity compared to bare silica, while maintaining excellent selectivity for polar compounds.
Features & Benefits:
Versatile Separation Modes: Suitable for normal-phase, HILIC, and size-exclusion (SEC) methods.
Reduced Silanol Activity: Compared to unbonded silica, reduces tailing for basic compounds.
Improved Sample Recovery: Minimizes strong interactions, enabling better peak shapes and recoveries.
Stable and Reproducible: Excellent batch-to-batch consistency for reliable performance.
Compatible with Aqueous and Organic Solvents: Ideal for diverse method development.
Typical Applications:
Analysis of carbohydrates, glycopeptides, and other highly polar compounds
Separation of polar pharmaceuticals, metabolites, and natural products
Hydrophilic interaction chromatography (HILIC) for peptides and polar drug candidates
Normal-phase separations in polar solvents
Used in bioanalytical and QC environments for their selectivity and stability
