An HPLC guard holder (also called a guard column holder or guard cartridge holder) is the hardware used to house a guard cartridge placed upstream of the analytical HPLC column. It protects the main column from contaminants and particulate matter, extending column life.
Removes strongly retained contaminants before they reach the analytical column
Protects against sample matrix impurities
Reduces column fouling and backpressure increase
Saves money by replacing only the guard cartridge instead of the entire column